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A combination of three-point bending tests and atomic force microscopy is used to quantify the impact of gold nanoparticle entrapment on the apparent Young's modulus of the nanocomposite. We show that at nanoscale the gold particles are effectively embedded in the bundle and have little influence on the nanoscale distribution of stresses and strains. When considering macroscale phenomena, however, a significantly increased ductility is observed, which is attributed to a change in the nanoscale distribution of stresses and strains within the bundle. We show that these changes cannot be explained by a straightforward scaling of Young's modulus based on the nanoparticle volume fraction. Instead, the altered macroscopic stress-strain curves are best explained by a modified continuum mechanics model that takes into account the size of the entrapped particles. In particular, the entrapped particles are shown to result in significantly higher modulus of the bundle surface layer.Risk factors for failure of the first trimester combined screening test (nuchal translucency and serum free beta-human chorionic gonadotropin). To determine the risk factors for failure of the first trimester combined screening test (cFT) in a hospital-based screening programme. The screening results of 1824 pregnant women, between 7 and 13 weeks of gestation, who had undergone screening between 1 September 2008 and 1 February 2011 at the Department of Obstetrics and Gynaecology, University Hospital of Heraklion, Crete, Greece, were analysed. The results of the cFT and the diagnosis of fetal anomaly or chromosomal abnormality, as well as the results of obstetric ultrasonography were collected. 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